Changes

<u>'''Nucleated red blood cells (metarubricytes)'''.</u> These are immature red cells, which retain a condensed nucleus.  

<u>'''Nucleated red blood cells (metarubricytes)'''.</u> These are immature red cells, which retain a condensed nucleus.  

<u>'''Spherocytes''':</u> These are spherical erythrocytes which appear smaller in diameter, stain more densely and lack central pallor. They are more obvious in canine blood (feline erythrocytes naturally lack central pallor) and are most commonly associated with IMHA. Other causes include snake bite, zinc toxicity and bee stings.

<u>'''Spherocytes''':</u> These are spherical erythrocytes which appear smaller in diameter, stain more densely and lack central pallor. They are more obvious in canine blood (feline erythrocytes naturally lack central pallor) and are most commonly associated with IMHA. Other causes include snake bite, zinc toxicity and bee stings.

=== Other morphological changes ===

=== Other morphological changes ===

'''<u>Eosinophil.</u>''' Mature eosinophils have a segmented nucleus and red intracytoplasmic granules. The granules in the dog are round and vary in size. In the cat they are small, uniform in size and rod shaped while in the horse the granules are round and very large. In rabbits, eosinophils have larger red granules than neutrophils although often the two cell types are difficult to differentiate and may be counted together as heterophils. Band eosinophils are immature cells showing less distinct nuclear segmentation.  

'''<u>Eosinophil.</u>''' Mature eosinophils have a segmented nucleus and red intracytoplasmic granules. The granules in the dog are round and vary in size. In the cat they are small, uniform in size and rod shaped while in the horse the granules are round and very large. In rabbits, eosinophils have larger red granules than neutrophils although often the two cell types are difficult to differentiate and may be counted together as heterophils. Band eosinophils are immature cells showing less distinct nuclear segmentation.  

[[File:NWLLabfacts 21.jpg|thumb|Basophil NationWide Laboratories]]

[[File:NWLLabfacts 21.jpg|thumb|Basophil NationWide Laboratories]]

'''<u>Basophil.</u>''' Rare in blood smears from healthy animals. Basophils are similar in size to eosinophils, with a segmented, ribbon-like nucleus and variable numbers of cytoplasmic granules. In dogs these are deep purple and sparse. Cats have more numerous lilac coloured granules with occasional deep purple granules.

'''<u>Basophil.</u>''' Rare in blood smears from healthy animals. Basophils are similar in size to eosinophils, with a segmented, ribbon-like nucleus and variable numbers of cytoplasmic granules. In dogs these are deep purple and sparse. Cats have more numerous lilac coloured granules with occasional deep purple granules.

[[File:NWLLabfacts 22.jpg|thumb|Mast cell NationWide Labs]]

[[File:NWLLabfacts 22.jpg|thumb|Mast cell NationWide Labs]]

<u>'''Lymphocyte'''</u>. Mature lymphocytes are small cells with round, occasionally cleft nuclei which are approximately one red cell width in diameter; they have condensed nuclear chromatin and a narrow rim of pale cytoplasm.  

<u>'''Lymphocyte'''</u>. Mature lymphocytes are small cells with round, occasionally cleft nuclei which are approximately one red cell width in diameter; they have condensed nuclear chromatin and a narrow rim of pale cytoplasm.  

'''<u>Reactive lymphocyte.</u>''' Slightly larger than a mature lymphocyte. Cells have round nuclei with condensed nuclear chromatin, surrounded by a rim of pale basophilic cytoplasm.

'''<u>Reactive lymphocyte.</u>''' Slightly larger than a mature lymphocyte. Cells have round nuclei with condensed nuclear chromatin, surrounded by a rim of pale basophilic cytoplasm.

[[File:NWLLabfacts 24.jpg|thumb|Lymphoblast NationWide Labs]]

[[File:NWLLabfacts 24.jpg|thumb|Lymphoblast NationWide Labs]]

<u>'''Lymphoblast.'''</u> A large cell with a large nucleus, two to three red cell widths in diameter, with one or more prominent nucleoli. These are rarely seen in blood smears from healthy animals but may be present with lymphoid neoplasia.

<u>'''Lymphoblast.'''</u> A large cell with a large nucleus, two to three red cell widths in diameter, with one or more prominent nucleoli. These are rarely seen in blood smears from healthy animals but may be present with lymphoid neoplasia.

[[File:NWLLabfacts 25.jpg|thumb|Large granular Lymphocyte NationWide Labs]]

[[File:NWLLabfacts 25.jpg|thumb|Large granular Lymphocyte NationWide Labs]]

 

'''<u>Large granular lymphocyte</u>'''. Lymphocyte containing several prominent magenta coloured cytoplasmic granules. Rarely seen in peripheral blood but are numerous in large granular cell leukaemia in the dog  

'''<u>Large granular lymphocyte</u>'''. Lymphocyte containing several prominent magenta coloured cytoplasmic granules. Rarely seen in peripheral blood but are numerous in large granular cell leukaemia in the dog  

<u>'''Monocyte'''</u>. These are large cells with a deeply indented nucleus showing pale, finely granular nuclear chromatin. They have a moderate amount of blue-grey cytoplasm, which may contain vacuoles.  

<u>'''Monocyte'''</u>. These are large cells with a deeply indented nucleus showing pale, finely granular nuclear chromatin. They have a moderate amount of blue-grey cytoplasm, which may contain vacuoles.  

[[File:NWL 3.jpg|thumb|Anaplasma platys elementary bodies NationWide Labs]]

[[File:NWL 3.jpg|thumb|Anaplasma platys elementary bodies NationWide Labs]]

[[File:NWL 4.jpg|thumb|Hepatozoon gametocytes and Ehrlichia Morula NationWide Labs]]

[[File:NWL 4.jpg|thumb|Hepatozoon gametocytes and Ehrlichia Morula NationWide Labs]]

[[File:NWL 6.jpg|thumb|Macrothrombocyte Nation Wide Labs (the one in the middle)]]

[[File:NWL 6.jpg|thumb|Macrothrombocyte Nation Wide Labs (the one in the middle)]]