Changes

== Introduction of GGT ==

== Introduction of GGT ==

The highest concentration of GGT is found in the cells of the renal tubules but, as it is excreted in the urine, levels do not rise in response to renal damage. Circulating enzyme is considered to originate from the liver (biliary epithelial cells and hepatocytes) and, as with [[Alkaline phosphatase|ALP]], levels increase in response to cholestasis. GGT is found lower in the biliary tree than ALP but is not specific in differentiating hepatocellular from cholestatic disease. In the dog, steroid induction of GGT occurs but it is less influenced by barbiturate therapy and may be useful in monitoring therapy and screening for barbiturate induced hepatopathy. GGT is considered a specific indicator of hepatobiliary disease in the cat.

The highest concentration of GGT is found in the cells of the renal tubules but, as it is excreted in the urine, levels do not rise in response to renal damage. Circulating enzyme is considered to originate from the liver (biliary epithelial cells and hepatocytes) and, as with [[Alkaline phosphatase|ALP]], levels increase in response to cholestasis. GGT is found lower in the biliary tree than ALP but is not specific in differentiating hepatocellular from cholestatic disease. In the dog, steroid induction of GGT occurs but it is less influenced by barbiturate therapy and may be useful in monitoring therapy and screening for barbiturate induced hepatopathy. GGT is considered a specific indicator of hepatobiliary disease in the cat.