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In severe toxaemia, neutrophils may show cytoplasmic vacuolation due to degranulation of lysosomes during disturbed maturation.
 
In severe toxaemia, neutrophils may show cytoplasmic vacuolation due to degranulation of lysosomes during disturbed maturation.
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  '''<u>Hypersegmented neutrophil.</u>''' There are more than 5 nuclear lobes. Found in dogs on corticosteroid therapy (which prolongs the half life of the neutrophil) and may be associated with uraemia. Also seen in Poodles with familial macrocytosis.  
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'''<u>Hypersegmented neutrophil.</u>''' There are more than 5 nuclear lobes. Found in dogs on corticosteroid therapy (which prolongs the half life of the neutrophil) and may be associated with uraemia. Also seen in Poodles with familial macrocytosis. <gallery widths="300">
<gallery widths="300">
   
File:NWLLabfacts 19.jpg|'''Hypersegmented neutrophil''' ©NationWide Laboratories 2017  
 
File:NWLLabfacts 19.jpg|'''Hypersegmented neutrophil''' ©NationWide Laboratories 2017  
 
</gallery>
 
</gallery>

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