Diagnosis of cobalamin deficiency is based on presence of low fasted serum cobalamin level. If the patient is not fasted prior to testing, falsely increased cobalamin concentrations may be noted. [[Nutrition Glossary#Megaloblastic Anaemia|Megaloblastic anaemia]] and [[neutropenia]] with hypersegmentation may be seen on haematology profile. Diagnosis is also made on clinical signs consistent with deficiency and evaluation of diet. | Diagnosis of cobalamin deficiency is based on presence of low fasted serum cobalamin level. If the patient is not fasted prior to testing, falsely increased cobalamin concentrations may be noted. [[Nutrition Glossary#Megaloblastic Anaemia|Megaloblastic anaemia]] and [[neutropenia]] with hypersegmentation may be seen on haematology profile. Diagnosis is also made on clinical signs consistent with deficiency and evaluation of diet. |