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Inherited disorders of Leucocytes (view source)
Revision as of 15:39, 21 April 2022
, 15:39, 21 April 2022no edit summary
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==B2 Integrin adhesion molecule deficiencies==
==B2 Integrin adhesion molecule deficiencies==
This leucocyte adhesion deficiency-1 (LAD-1) results in decreased adhesion, impaired chemotaxis and minimal bactericidal function. Monocyte activity is also impaired. Affected animals suffe from recurrent bacterial and fungal infections without purulent inflammation. There is frequently a peripheral neutrophila, +/- a left shift and monocytosis. This condition has been reported in Irish Setters and Holstein cattle.
This leucocyte adhesion deficiency-1 (LAD-1) results in decreased adhesion, impaired chemotaxis and minimal bactericidal function. Monocyte activity is also impaired. Affected animals suffe from recurrent bacterial and fungal infections without purulent inflammation. There is frequently a peripheral neutrophila, +/- a left shift and monocytosis. This condition has been reported in Irish Setters and Holstein cattle.