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<big><center>[[Infectious agents and parasites|'''BACK TO INFECTIOUS AGENTS AND PARASITES''']]</center></big>
 
<big><center>[[Infectious agents and parasites|'''BACK TO INFECTIOUS AGENTS AND PARASITES''']]</center></big>
 
<big><center>[[Bacteria|'''BACK TO BACTERIA''']]</center></big>
 
<big><center>[[Bacteria|'''BACK TO BACTERIA''']]</center></big>
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* [[General Pathology - Oedema#Permeability type|Permeability types of pulmonary oedema]]
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* Can cause haemorrhagic disease by [[General Pathology - Haemostasis#Secondary Thrombocytopenic Disease|secondary thrombocytopenic disease]].
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*May infect [[Joints - inflammatory#In Sheep|joints of sheep]]  [[Joints - inflammatory#In Pigs|arthritis in pigs]],
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*''Staphylococcus'' spp. in [[Bacterial skin infections#Impetigo|impetigo]]
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==Staphylococcus hyicus==
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*Pigs - '''greasy pig disease'''
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*Exudative epidermitis due to ''Staphylococcus hyicus'' is a worldwide problem in piglets. 
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*The organism can often be isolated from the mucosa and skin of healthy adult pigs, and can persist in the environment for long periods. 
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*Disease occurs only in young piglets up to about 35 days of age. 
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*Passive transfer of antibodies from immune sows and development of immunity with age appear to adequately protect against disease. 
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*Piglets from non-immune sows are predisposed. 
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*Skin trauma, such as due to fighting, allowing entry of infective organisms is also considered a risk factor in this disease.
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===[[Bacterial skin infections#Greasy pig disease|Pathology]]===
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===Pathogenesis===
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*''Staphylococcus hyicus'' produces an exfoliative toxin of approximately 30 kDa that causes separation of cells in the upper stratum spinosum resulting in rapid intraepidermal spread of organisms. 
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*Death of affected piglets is common and is attributed to dehydration, septicemia, or both. 
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*This porcine disorder has been likened to “scalded skin syndrome” in human neonates, due to skin infection by exfoliative toxin-producing ''Staphylococcus aureus''.
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===Differential diagnosis===
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*mange (Sarcoptes scabiei var. suis)
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*swine parakeratosis (zinc and essential fatty acid deficiency)
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*porcine juvenile pustular psoriasiform dermatitis (collarettes or rings typically on the ventrum of young pigs)
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*dermatosis vegetans (associated with a giant cell pneumonia)
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*dermatophytosis (most commonly Microsporum nanum)
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==Staphylococcus aureus==
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* May cause [[Intestines - disease due to pathogens#Staphylococcus|gastroenteritis]] in small animals.
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*[[Muscles - inflammatory#Botryomycosis|Botryomycosis]] in muscles
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*In botryomycosis in [[Bacterial skin infections#Bacterial granulomatous dermatitis|skin]]
      
===Overview===
 
===Overview===
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===Exudative epidermitis (greasy pig disease===
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===Exudative epidermitis ([[Bacterial skin infections#Greasy pig disease|Pathology]])===
    
*Worldwide disease of pigs under 3 months of age caused by ''S. hyicus''
 
*Worldwide disease of pigs under 3 months of age caused by ''S. hyicus''
*Highly contagious
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*Highly contagious and persists in the environment for long periods
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*''S. hyicus'' produces exfoliative toxin that causes separation of cells in stratum spinosum resulting in rapid intraepidermal spread of organisms
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*Similar to “scalded skin syndrome” in human neonates, due to skin infection by exfoliative toxin-producing ''Staphylococcus aureus''
 
*Excessive sebacious secretion and exudation on surface of skin
 
*Excessive sebacious secretion and exudation on surface of skin
 
*Pigs are anorexic, febrile, depressed and have a greasy, non-pruritic dermatitis
 
*Pigs are anorexic, febrile, depressed and have a greasy, non-pruritic dermatitis
*Acute death in piglets under 3 weeks
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*Acute death in piglets under 3 weeks due to dehydration and septicaemia
 
*20-100% morbidity; up to 90% mortality
 
*20-100% morbidity; up to 90% mortality
 
*Organism enters skin via abrasions e.g. bite wounds
 
*Organism enters skin via abrasions e.g. bite wounds
 
*Carried in vaginal mucosa and skin of sows
 
*Carried in vaginal mucosa and skin of sows
 
*Predisposed by lack of milk, weaning and other infections
 
*Predisposed by lack of milk, weaning and other infections
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*Piglets from non-immune sows are predisposed
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*Passive transfer of antibodies from immune sows and development of immunity with age protect against disease
 
*Isolation from skin lesions
 
*Isolation from skin lesions
 
*Early systemic antibiotics amd topical antiseptics/antibiotics useful
 
*Early systemic antibiotics amd topical antiseptics/antibiotics useful
 
*Disinfection after outbreak
 
*Disinfection after outbreak
 
*Wash sows before farrowing
 
*Wash sows before farrowing
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*Differential diagnosis:
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**Mange (''Sarcoptes scabiei var. suis'')
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**Swine parakeratosis (zinc and essential fatty acid deficiency)
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**Porcine juvenile pustular psoriasiform dermatitis (collarettes or rings typically on the ventrum of young pigs)
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**Dermatosis vegetans (associated with a giant cell pneumonia)
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**Dermatophytosis (most commonly ''Microsporum nanum'')
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===Botryomycosis===
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===[[Muscles - inflammatory#Botryomycosis|Botryomycosis]]===
    
*Chronic, suppurative granulomatous condition  
 
*Chronic, suppurative granulomatous condition  
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*''S. intermedius'' causes [[Bacterial skin infections#Deep pyoderma|deep pyoderma]], otitis externa, mastitis, endometritis, cystitis, osteomyelitis, wound infections, [[Joints - inflammatory#In Dogs|dyscospondylitis]]
 
*''S. intermedius'' causes [[Bacterial skin infections#Deep pyoderma|deep pyoderma]], otitis externa, mastitis, endometritis, cystitis, osteomyelitis, wound infections, [[Joints - inflammatory#In Dogs|dyscospondylitis]]
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*''S. aureus'' may cause [[Intestines - disease due to pathogens#Staphylococcus|gastroenteritis]]
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===Other infections===
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**[[Bacterial skin infections#Impetigo|Impetigo]] in cattle and pigs
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** [[General Pathology - Oedema#Permeability type|Permeability types of pulmonary oedema]]
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**Haemorrhagic disease by [[General Pathology - Haemostasis#Secondary Thrombocytopenic Disease|secondary thrombocytopenic disease]]
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**May infect [[Joints - inflammatory#In Sheep|joints of sheep]]; [[Joints - inflammatory#In Pigs|arthritis in pigs]]
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