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*AKA contagious pustular dermatitis, Orf, etc
 
*AKA contagious pustular dermatitis, Orf, etc
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===General information===
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====General information====
 
*CE is an acute debilitating but rarely fatal skin disease of sheep, goats and incidentally of ruminants and humans.  
 
*CE is an acute debilitating but rarely fatal skin disease of sheep, goats and incidentally of ruminants and humans.  
 
*The disease is generally mild.  
 
*The disease is generally mild.  
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*PPV's generally exhibit a highly restricted host range but in all cases can also infect man.
 
*PPV's generally exhibit a highly restricted host range but in all cases can also infect man.
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===Aetiological agent===
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====Aetiological agent====
 
*The virus is a large, enveloped, highly epitheliotropic, DNA virus which is ovoid in shape and measures 220‑300 x 140‑170 nm.  *There are over 100 polypeptides in the virion.   
 
*The virus is a large, enveloped, highly epitheliotropic, DNA virus which is ovoid in shape and measures 220‑300 x 140‑170 nm.  *There are over 100 polypeptides in the virion.   
 
*The core proteins include a transcriptase and several other enzymes.   
 
*The core proteins include a transcriptase and several other enzymes.   
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*The virus is resistant to desiccation.
 
*The virus is resistant to desiccation.
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===Pathology===
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====Pathology====
 
[[Image:f00358.jpg]]
 
[[Image:f00358.jpg]]
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===Differential diagnosis===
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====Differential diagnosis====
 
*  Sheep pox: A more severe disease, it is characterized by elevated papules distributed diffusely over the skin surface.  Inclusion bodies are often seen, but there is no down‑growth of epidermis.  There is a high mortality.
 
*  Sheep pox: A more severe disease, it is characterized by elevated papules distributed diffusely over the skin surface.  Inclusion bodies are often seen, but there is no down‑growth of epidermis.  There is a high mortality.
 
*  Ulcerative dermatosis:  Characterized by ulcers and crusts on the skin of the face, feet and genitalia.  The lesions are not elevated because there is no epithelial hyperplasia.
 
*  Ulcerative dermatosis:  Characterized by ulcers and crusts on the skin of the face, feet and genitalia.  The lesions are not elevated because there is no epithelial hyperplasia.
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