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Skin Immunologic - Pathology (view source)
Revision as of 21:27, 20 August 2008
, 21:27, 20 August 2008no edit summary
*Cytotoxic reaction
*Cytotoxic reaction
*IgG and IgM interaction with antigens bound to cellular membranes
*IgG and IgM interaction with antigens bound to cellular membranes
*Often involves [[Complement - Anatomy & Physiology#Complement Fixation Pathways|complement fixation]] -> cellular damage
*Often involves [[Complement - WikiBlood#Complement Fixation Pathways|complement fixation]] -> cellular damage
*In skin - circulating antibody to proteins of desmosomes in intercellular areas along basement membranes at epidermal-dermal junction
*In skin - circulating antibody to proteins of desmosomes in intercellular areas along basement membranes at epidermal-dermal junction
*Includes:
*Includes:
===Type III reactions===
===Type III reactions===
*[[Complement - Anatomy & Physiology#Complement Fixation Pathways|Complement fixing]] immune complexes
*[[Complement - WikiBlood#Complement Fixation Pathways|Complement fixing]] immune complexes
*IgG or IgM
*IgG or IgM
*Complexes deposit in tissue -> fix complement -> cytokines and othe factors attrack neutrophils -> release lysosomal enzymes, activation of complement and coagulation, platelet aggregation -> tissue damage
*Complexes deposit in tissue -> fix complement -> cytokines and othe factors attrack neutrophils -> release lysosomal enzymes, activation of complement and coagulation, platelet aggregation -> tissue damage