Changes

**LPS O antigens prevent damage to bacterial cell wall by complement

**LPS O antigens prevent damage to bacterial cell wall by complement

**LPS also causes endotoxaemia, and may contribute to local inflammatory response damaging intestinal cells to cause diarrhoea

**LPS also causes endotoxaemia, and may contribute to local inflammatory response damaging intestinal cells to cause diarrhoea

**Endotoxic shock during septicaemic [[Intestines - Fibrinous/ Haemorrhagic Enteritis#Salmonellosis|salmonellosis]] due to LPS  

**Endotoxic shock during septicaemic [[Intestines Fibrinous/Haemorrhagic Enteritis - Pathology#Salmonellosis|salmonellosis]] due to LPS  

**Septicaemia may cause [[Bacterial skin infections - Pathology#Systemic bacterial infections|cyanosis of extremities]]

**Septicaemia may cause [[Bacterial skin infections - Pathology#Systemic bacterial infections|cyanosis of extremities]]

**Intracellular carriage if bacteria no completely removed

**Intracellular carriage if bacteria no completely removed

*Most human infections contracted from animals, especially poulty and cattle

*Most human infections contracted from animals, especially poulty and cattle

*Some serotypes are host-specific, some infect a wide range of species

*Some serotypes are host-specific, some infect a wide range of species

*Healthy adult carnivores are resistant to [[Intestines - Fibrinous/ Haemorrhagic Enteritis#Salmonellosis|salmonellosis]]

*Healthy adult carnivores are resistant to [[Intestines Fibrinous/Haemorrhagic Enteritis - Pathology#Salmonellosis|salmonellosis]]

*Clinical outcome depends on number of bacteria ingested, virulence of serotype, susceptibility of host

*Clinical outcome depends on number of bacteria ingested, virulence of serotype, susceptibility of host

*Young and debilitated animals susceptible

*Young and debilitated animals susceptible

**''S.'' Typhi, ''S.'' Paratyphi: infect humans

**''S.'' Typhi, ''S.'' Paratyphi: infect humans

**''S.'' Montevideo produces outbreaks from contaminated imported meat and bone meal  

**''S.'' Montevideo produces outbreaks from contaminated imported meat and bone meal  

*Enteric [[Intestines - Fibrinous/ Haemorrhagic Enteritis#Salmonellosis|salmonellosis]]:

*Enteric [[Intestines Fibrinous/Haemorrhagic Enteritis - Pathology#Salmonellosis|salmonellosis]]:

**Enterocolitis occurs in most farm animal species affecting all ages

**Enterocolitis occurs in most farm animal species affecting all ages

**[[Intestines - Ulcerative Enteritis|Ulcerative enteritis]]  

**[[Intestines - Ulcerative Enteritis|Ulcerative enteritis]]  

**Milder syndrome where endemic on farms, possibly due to acquired immunity

**Milder syndrome where endemic on farms, possibly due to acquired immunity

**Chronic enterocolitis can occur in surviving pigs, cattle, horses, causing intermittent fever, soft faeces and gradual weight loss

**Chronic enterocolitis can occur in surviving pigs, cattle, horses, causing intermittent fever, soft faeces and gradual weight loss

*Septicaemic [[Intestines - Fibrinous/ Haemorrhagic Enteritis#Salmonellosis|salmonellosis]]:

*Septicaemic [[Intestines Fibrinous/Haemorrhagic Enteritis - Pathology#Salmonellosis|salmonellosis]]:

**Most common in calves, neonatal foals, pigs under one month

**Most common in calves, neonatal foals, pigs under one month

**Sudden onset fever, depression, recumbency

**Sudden onset fever, depression, recumbency

**Can cause haemorrhagic disease by [[General Pathology - Haemostasis#Secondary Thrombocytopenic Disease|secondary thrombocytopenic disease]]

**Can cause haemorrhagic disease by [[General Pathology - Haemostasis#Secondary Thrombocytopenic Disease|secondary thrombocytopenic disease]]

**''S.'' Cholerae-Suis in pigs causes blue discoloration of ears and snout; co-infection with viruses causes severe clinical forms of disease

**''S.'' Cholerae-Suis in pigs causes blue discoloration of ears and snout; co-infection with viruses causes severe clinical forms of disease

*Bovine [[Intestines - Fibrinous/ Haemorrhagic Enteritis#Salmonellosis|salmonellosis]]:

*Bovine [[Intestines Fibrinous/Haemorrhagic Enteritis - Pathology#Salmonellosis|salmonellosis]]:

**Syndrome of fever and diarrhoea (with dysentery), often fatal, in calves and adult cattle

**Syndrome of fever and diarrhoea (with dysentery), often fatal, in calves and adult cattle

**Abdominal pain in adult cattle due to necrotic bowel

**Abdominal pain in adult cattle due to necrotic bowel

***Most survivors become subclinical excretors

***Most survivors become subclinical excretors

***May become latent carriers with no excretion

***May become latent carriers with no excretion

*<div id="Spleen">[[Intestines - Fibrinous/ Haemorrhagic Enteritis#Salmonellosis|Salmonellosis]] in poultry:

*<div id="Spleen">[[Intestines Fibrinous/Haemorrhagic Enteritis - Pathology#Salmonellosis|Salmonellosis]] in poultry:

**''S.'' Pullorum and ''S.'' Gallinarum now rare in UK due to eradication programs including the Pullorum test (whole blood slide agglutination to detect antibody to both ''S.'' Pullorum and ''S'' Gallinarum)

**''S.'' Pullorum and ''S.'' Gallinarum now rare in UK due to eradication programs including the Pullorum test (whole blood slide agglutination to detect antibody to both ''S.'' Pullorum and ''S'' Gallinarum)

**These ''Salmonellae'' can infect the ovaries of hens and be transmitted via eggs

**These ''Salmonellae'' can infect the ovaries of hens and be transmitted via eggs