Changes

Jump to navigation Jump to search

Major Histocompatability Complexes (view source)

Revision as of 15:15, 28 August 2008

10 bytes removed ,  15:15, 28 August 2008
→‎Interaction of MHC With Antigen
Line 69: Line 69:  
**** The peptide-MHC class II complex gets transported to the cell surface
 
**** The peptide-MHC class II complex gets transported to the cell surface
   −
==Interaction of MHC With Antigen==
+
=Interaction of MHC With Antigen=
 
* The MHC molecules do not recognise specific amino acid sequences of antigens
 
* The MHC molecules do not recognise specific amino acid sequences of antigens
 
** Instead, they recognise particular motifs of amino acids
 
** Instead, they recognise particular motifs of amino acids
Line 82: Line 82:  
*** Is the target for T cell receptor recognition
 
*** Is the target for T cell receptor recognition
   −
===TCR-MHC Interaction===
+
==TCR-MHC Interaction==
 
* Only peptide associated with self-MHC will interact with and activate T-cells
 
* Only peptide associated with self-MHC will interact with and activate T-cells
 
** T-cells cannot be activated by a peptide on a foreign cell
 
** T-cells cannot be activated by a peptide on a foreign cell
Line 88: Line 88:  
*** This is the basis of graft rejection
 
*** This is the basis of graft rejection
   −
===The Genetics of the MHC===
+
==The Genetics of the MHC==
 
* Different individuals have different critical amino acids within the MHC
 
* Different individuals have different critical amino acids within the MHC
 
** I.e. different amino acids that determine peptide binding
 
** I.e. different amino acids that determine peptide binding
Line 96: Line 96:  
* MHC polymorphism has been best studied in the human
 
* MHC polymorphism has been best studied in the human
   −
===In the Human===
+
==In the Human==
 
* Humans express:
 
* Humans express:
 
** Three types (loci) of MHC class I molecules
 
** Three types (loci) of MHC class I molecules
Line 117: Line 117:  
** E.g. ruminants have no MHC class II DP
 
** E.g. ruminants have no MHC class II DP
   −
===MHC and Disease===
+
==MHC and Disease==
 
* Antigen from a pathogen has to be seen by the host MHC before an efficient immune response can occur
 
* Antigen from a pathogen has to be seen by the host MHC before an efficient immune response can occur
 
** There is therefore a constant evolutionary battle between the host and the pathogen
 
** There is therefore a constant evolutionary battle between the host and the pathogen
Bepocock
1,351

edits

Retrieved from "https://en.wikivet.net/Special:MobileDiff/32337"

Navigation menu