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*Predisposed to [[Pancreas - inflammatory|pancreatitis]] and may also have [[EPI|pancreatic insufficiency]]
*Predisposed to [[Pancreas - inflammatory|pancreatitis]] and may also have [[EPI|pancreatic insufficiency]]
*Persistent [[Pancreas - endocrine#Glucagonoma|increase in glucagon]] may cause hyperglycaemia
*Persistent [[Pancreas - endocrine#Glucagonoma|increase in glucagon]] may cause hyperglycaemia
*More common in mature dogs, twice as common in females than in males
===Aetiology===
===Aetiology===
*Fatty change is consistently present in the liver and kidneys
*Fatty change is consistently present in the liver and kidneys
*The lens in the eye is often opaque due to deposition of sorbitol causing it to swell (glucose is converted into sorbitol once the glycolytic pathway is saturated)
*The lens in the eye is often opaque due to deposition of sorbitol causing it to swell (glucose is converted into sorbitol once the glycolytic pathway is saturated)
*In immune-mediated isletitis - progressive lymphoplasmacytic infiltration and selective destruction of islet cells