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Major Histocompatability Complexes (view source)
Revision as of 12:55, 29 August 2008
, 12:55, 29 August 2008no edit summary
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[[Image:MHC.jpg|thumb|right|150px|Major Histocompatibility Complexes - B. Catchpole, RVC 2008]]
=Introduction=
=Introduction=
T-cells rely on Major Histocompatability Complexes (MHC) to present antigen fragments for their recognition. MHC has evolved to form two classes for antigen presentation: '''MHC I''' presents digestion fragments from antigen in '''cellular cytoplasm''', and '''MHC II''' presents digestion fragments from antigen in the '''tissue fluid'''. As such, MHC I tends to bind slightly smaller peptides (~9 amino acids) than MHC II (~15 amino acids).
T-cells rely on Major Histocompatability Complexes (MHC) to present antigen fragments for their recognition. MHC has evolved to form two classes for antigen presentation: '''MHC I''' presents digestion fragments from antigen in '''cellular cytoplasm''', and '''MHC II''' presents digestion fragments from antigen in the '''tissue fluid'''. As such, MHC I tends to bind slightly smaller peptides (~9 amino acids) than MHC II (~15 amino acids).