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* CD4+ T cell mediated:
 
* CD4+ T cell mediated:
 
** Abnormal activation of macrophages in healthy tissues.
 
** Abnormal activation of macrophages in healthy tissues.
** Macrophage production of inflammatory mediators and MMP enzymes cause tissue damage.
+
** Macrophage production of inflammatory mediators and MMP (matrix metalloproteinase) enzymes cause tissue damage.
    
* CD8+ T cell mediated:
 
* CD8+ T cell mediated:
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