Changes

==Introduction==

==Introduction==

Production of IgM or IgG to cell surface antigens or extracellular matrix proteins.

Production of [[Immunoglobulin M - WikiBlood|IgM]] or [[Immunoglobulin G - WikiBlood|IgG] to cell surface antigens or extracellular matrix proteins.

==Mechanism==

==Mechanism==

1. Antibody dependent cell cytotoxicity (ADCC)

1. Antibody dependent cell cytotoxicity (ADCC)

* Pemphigus vulgaris

* [[Autoimmune Diseases - WikiBlood|Pemphigus vulgaris]]

* Bullous pemphigoid

* [[Autoimmune Diseases - WikiBlood|Bullous pemphigoid]]

2. Complement mediated lysis

2. [[Complement - WikiBlood|Complement]] mediated lysis

* Self RBC antigen:

* Self [[Erythrocytes - WikiBlood|RBC]] antigen:

** Immune mediated haemolytic anaemia

** [[Autoimmune Diseases - WikiBlood|Immune mediated haemolytic anaemia]]

* Foreign RBC:

* Foreign [[Erythrocytes - WikiBlood|RBC]]:

** Blood transfusion reaction

** Blood transfusion reaction

** Haemolytic disease of new born (Rhesus disease in humans and neonatal isoerythrolysis in foals and kittens)

** Haemolytic disease of new born (Rhesus disease in humans and neonatal isoerythrolysis in foals and kittens)