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===2. Granulomatous===
 
===2. Granulomatous===
* Intense activation of T cells, cytokine release and macrophage activation cause necrosis of surrounding tissue, granuloma formation leading to destruction of host tissue.
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* Intense activation of T cells, [[Cytokine - WikiBlood|cytokine]] release and [[Macrophage - WikiBlood|macrophage]] activation cause necrosis of surrounding tissue, granuloma formation leading to destruction of host tissue.
 
* Composed of epithelial cell, giant cells and macrophages in response to infection, for example:
 
* Composed of epithelial cell, giant cells and macrophages in response to infection, for example:
 
** ''Mycobacterium tubercle''
 
** ''Mycobacterium tubercle''
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