Changes

===2. Granulomatous===

===2. Granulomatous===

* Intense activation of T cells, cytokine release and macrophage activation cause necrosis of surrounding tissue, granuloma formation leading to destruction of host tissue.

* Intense activation of T cells, [[Cytokine - WikiBlood|cytokine]] release and [[Macrophage - WikiBlood|macrophage]] activation cause necrosis of surrounding tissue, granuloma formation leading to destruction of host tissue.

* Composed of epithelial cell, giant cells and macrophages in response to infection, for example:

* Composed of epithelial cell, giant cells and macrophages in response to infection, for example:

** ''Mycobacterium tubercle''

** ''Mycobacterium tubercle''