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Limb Development - Anatomy & Physiology (view source)
Revision as of 18:41, 29 August 2008
, 18:41, 29 August 2008→Limb Bud Formation
==Limb Bud Formation==
==Limb Bud Formation==
*The limbs begin as lateral proliferations of the mesenchymal lateral plate mesoderm, which is covered by ectoderm.
**The lateral plate mesoderm proliferates in a lateral direction along the entire midline, but then stops at the region of the interlimb (area between the limbs).
**This produces small buds, which will continue to grow to eventually form the limbs.
*Proliferation of the lateral plate mesoderm cannot sustain entire limb growth; the '''apical ectodermal ridge (AER)''' maintains growth.
**The AER develops as mesenchymal cells cause cells of the overlying ectoderm to change their morphology from cuboidal to columnar.
**This can be seen when looking at the limb bud in a distal to poximal direction.
==Patterning of the Limb==
==Patterning of the Limb==