Changes

Can be caused by

Can be caused by

*Absolute deficiency of insulin due to [[Pancreas - endocrine#Degenerative pathology|degenerative changes]] in beta cells

*Absolute deficiency of insulin due to [[Pancreas - endocrine#Degenerative pathology|degenerative changes]] in beta cells

*Antagonism of insulin by hormones from the adrenal and thyroid glands, anterior pituitary causing high levels of blood glucose

*Antagonism of insulin by hormones from the adrenal and thyroid glands, anterior pituitary causing high levels of blood glucose (e.g. progesterone may initiate postoestrus DM in the bitch)

*Complication of pancreatic fibrosis

*Complication of pancreatic fibrosis

*Insulin binding antibodies, insulinase and plasma antagonists imbalance

*Insulin binding antibodies, insulinase and plasma antagonists imbalance

*Chronic insulin resistance results in hyperinsulinism leading to islet exhaustion

*Chronic insulin resistance results in hyperinsulinism leading to islet exhaustion

===Clinical signs===

===Clinical signs===