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Bone & Cartilage Development - Anatomy & Physiology (view source)
Revision as of 09:30, 31 August 2008
, 09:30, 31 August 2008no edit summary
<big><center>[[Developmental Biology - Anatomy & Physiology|'''BACK TO DEVELOPMENTAL BIOLOGY]]</center></big>
<big><center>[[Developmental Biology - Anatomy & Physiology|'''BACK TO DEVELOPMENTAL BIOLOGY]]</center></big>
==Introduction==
Osteogenesis is the formation of bone. Bone forms from one of three lineages; the skull forms from neural cest; the limb skeleton forms from lateral plate mesoderm; and the axial skeleton forms from paraxial mesoderm (sclerotome). There are two methods of osteogenesis. Both involve the transformation of pre - existing mesenchymal tissue into bone.
#'''Intramembranous Ossification''' - direct conversion of mesenchymal tissue into bone. Occurs in production of the skull.
#'''Endochondrial Ossification''' - mesechymal tissue first differentiates into cartilage, then into bone. This occurs in the production of limb and axial skeleton.
#*Limb cartilage is produced in a proximal to distal direction as a continuous structure. It becomes punctuated with joints later, and then converted to bone.