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#Blood vessels invade the central region of the diaphysis to transport bone marrow stem cells and osteoclasts.
 
#Blood vessels invade the central region of the diaphysis to transport bone marrow stem cells and osteoclasts.
 
#*The osteoclasts break down the cartilage matrix to allow room for the bone marrow.
 
#*The osteoclasts break down the cartilage matrix to allow room for the bone marrow.
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#There is no perichondrium surrounding the eiphysis.
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#*This allows for expansion in length of the bone, but means that there are no surrounding oasteoblasts to invade.
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#*To achieve osteogenesis, blood vessels invade from the diaphysis and carry osteoblasts with them.
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#*''In the epiphysis, osteoblasts initiate bone growth from the inside - out. This is called secondary ossification.''
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#*In some mammals, secondary ossification occurs after birth.
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#The bone becomes covered in a layer containing osteoblasts.
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*Cartilage is ''not replaced by bone'' in two areas:
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:In between the diaphysis and epiphysis, a region called the '''epiphyseal growth plate (EPG)'''.
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:At the ends of the epiphysis, between the joints. Acts as a '''shock absorber'''.
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==Bone Growth==
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