*Mucus - inhibits contact and protects the mucosal surface
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*Digestive enzymes -
==== Epithelium ====
==== Epithelium ====
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*"Tight junctions" between epithelial cells prevent entry of macromolecules and pathogens into the intestinal tract.
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*Epithelial cells have a very high turnover rate thus preventing pathogens with a longer life cycle from successfully colonising.
==== Commensal flora ====
==== Commensal flora ====
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*Commensal flora competitively inhibit attachment of pathogens to enterocytes in addition to competing for nutrition and substrates. Many also produce inhibitory growth substances that are toxic to other bacteria (McGavin and Zachary, 2007.
==== Movement ====
==== Movement ====
==== Cell-mediated and humoural defences ====
==== Cell-mediated and humoural defences ====
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+
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References
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McGavin DM & Zachary, JF: Pathologic Basis of Veterinary Disease, 4th ed, pp. 301-393. Elsevier, St. Louis, Missouri, 2007.