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* Testosterone crosses the blood-brain barrier and is converted into oestradiol.
 
* Testosterone crosses the blood-brain barrier and is converted into oestradiol.
* In the brain, oestradiol 'defeminizes' the hypothalamus.
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* In the brain, oestradiol 'defeminizes' the [[Hypothalamus_-_Anatomy_%26_Physiology|hypothalamus]].
 
* Surge centre function is minimized.
 
* Surge centre function is minimized.
 
* Complete 'defeminization' of the brain requires postnatal exposure to androgens.
 
* Complete 'defeminization' of the brain requires postnatal exposure to androgens.
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