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Glomerular Apparatus and Filtration - Anatomy & Physiology (view source)
Revision as of 15:15, 7 September 2008
, 15:15, 7 September 2008→Factors Which Determine Selective Filtration
** The barrier has a net negative charge thanks to cells in the membrane having a negatively charged surface and a basal lamina with negatively charged glycoproteins.
** The barrier has a net negative charge thanks to cells in the membrane having a negatively charged surface and a basal lamina with negatively charged glycoproteins.
** Therefore negatively charged molecules are filtered less than positive or neutral ones
** Therefore negatively charged molecules are filtered less than positive or neutral ones
** Proteins are negatively charged this and their size prevents their filtration
** Proteins are negatively charged. This and their size prevents their filtration
* Protein binding
* Protein binding
** Drugs, ions or small molecules which are bound to protein are not filtered
** Drugs, ions or small molecules which are bound to protein are not filtered