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Major Histocompatability Complexes (view source)
Revision as of 13:25, 9 September 2008
, 13:25, 9 September 2008→The Genetics of the MHC (Polymorphism)
**Most polymorphic regions of class II are in the alpha 1 and beta 1 domains
**Most polymorphic regions of class II are in the alpha 1 and beta 1 domains
*Most polymorphisms are point mutations
*Most polymorphisms are point mutations
* There are millions of variations in antibodies and TCR
* There are millions of variations in [[Immunoglobulins - WikiBlood|antibodies]] and TCR
** However, with MHC there is very limited variation between molecules
** However, with MHC there is very limited variation between molecules
*Allelic variation within the MHC molecule occurs at the peptide binding site and on the top or sides of the binding cleft
*Allelic variation within the MHC molecule occurs at the peptide binding site and on the top or sides of the binding cleft