Changes

*LH causes the release of Prostaglandin E2 (PGE2) and Histamine. These both cause a general increase in blood supply to the Ovaries and an increase in the local blood supply to the dominant follicles.

*LH causes the release of Prostaglandin E2 (PGE2) and Histamine. These both cause a general increase in blood supply to the Ovaries and an increase in the local blood supply to the dominant follicles.

*The local increase in blood supply ensures that the dominant follicles recieve all the nutrients they require to reach maturation and ovulation.

*The local increase in blood supply ensures that the dominant follicles recieve all the nutrients they require to reach maturation and ovulation.

*The increase in blood supply also causes formation of oedema within the follicles due to increased hydrostatic pressure within the ovarian cappilaries. This oedema causes an increase in intra-follicular pressure.

*The increase in blood supply also causes formation of oedema within the follicles due to increased hydrostatic pressure within the ovarian capillaries. This oedema causes an increase in intra-follicular pressure.

'''Progesterone Synthesis'''

'''Progesterone Synthesis'''

*LH causes a shift from oestrogen to progesterone production by follicular Granulosa cells. This local increase in progesterone stimulates Theca cells to produce the enzyme Collagenase, which breakdown the collagen within the [[Female Reproductive Tract -The Ovary - Anatomy & Physiology|Tunica Albuginea]] weakening the follicle wall.

*LH causes a shift from oestrogen to progesterone production by follicular Granulosa cells. This local increase in progesterone stimulates Theca cells to produce the enzyme Collagenase, which breakdown the collagen within the [[Female Reproductive Tract -The Ovary - Anatomy & Physiology|Tunica Albuginea]] weakening the follicle wall.