* As the corpus luteum regresses between days 15-18, the colour rapidly changes to yellow, creamy yellow or buff.
* As the corpus luteum regresses between days 15-18, the colour rapidly changes to yellow, creamy yellow or buff.
* The mechanism of luteolysis is not fully understood in the sow.
* The mechanism of luteolysis is not fully understood in the sow.
−
** Corpora lutea are unresponsive to PGF2
+
** Corpora lutea are unresponsive to PGF2α until 12-23 days after obulation.
+
** During luteolysis, corpora lutea are invaded by macrophages.
+
** Macrophages produce Tumour Necrosis Factor (TNF).
+
** TNF and PGF2α probably work together to cause luteolysis.
+
** TNF also inhibits oestradiol production, thus eliminating the luteotrophic source.
+
* There is rapid regression of corpora lutea at the next oestrus, but throughout the next dioestrus the corpora lutea remain as distinct entities.
+
* After this they rapidly regress to grey pin-head foci on the ovary.
+
* During the luteal phase of the cycle, oestrogens are luteotrophic. This may prolong the lifespan of the corpora lutea for several weeks. The result of this is pseudopregnancy.
=== Endocrine Changes during the Oestrous Cycle ===
=== Endocrine Changes during the Oestrous Cycle ===