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**E.g. Canine Parvovirus
**E.g. Canine Parvovirus
*To prevent the spread of disease
*To prevent the spread of disease by virus excretion
**E.g. Rabies, FMDV
**E.g. Rabies, FMDV
*The goal is to vaccinate 90% of the population to reduce the amount of '''endemic''' virus until no new infections occur
*Once the disease risk is low, vaccination can be replaced by an eradication or quarantine programme
==How do vaccines work?
*Vaccination sets up memory to the viral infection
*High levels of cytotoxic T cells and neutralising antibody are activated in 1-2 days as a secondary response (instead of 4-10 days as a primary response)
*The infection is therefore prevented from taking hold causing lesions to develop
*Neutralising antibody blocks the attachment of virus to host cells receptors
*'''Endogenous vaccines''' are where the antigen are made as new proteins by the cell, bacterium or virus
**Involves MHC class I processing
**E.g. live virus, recombinant virus and DNA vaccines
*'''Exogenous vaccines''' are when the antigen is processed from the outside by endocytosis without any new proteins being made by the host cell
**involves MHC class II processing
==How do we vaccinate?==
==How do we vaccinate?==