Changes

*Vaccination sets up memory to the viral infection

*Vaccination sets up memory to the viral infection

*High levels of cytotoxic T cells and neutralising antibody are activated in 1-2 days as a secondary response (instead of 4-10 days as a primary response)

*High levels of [[T cell differentiation - WikiBlood#Cytotoxic T-Cells|cytotoxic T cells]] and neutralising [[Immunoglobulins - WikiBlood|antibody]] are activated in 1-2 days as a [[B cell differentiation - WikiBlood#Secondary T Cell Dependent Response|secondary response]] (instead of 4-10 days as a [[B cell differentiation - WikiBlood#T-Cell Dependent Response|primary response]])

*The infection is therefore prevented from taking hold causing lesions to develop

*The infection is therefore prevented from taking hold causing lesions to develop

*Neutralising antibody blocks the attachment of virus to host cells receptors

*Neutralising [[Immunoglobulins - WikiBlood|antibody]] blocks the attachment of virus to host cells receptors

*'''Endogenous vaccines''' are where the antigen are made as new proteins by the cell, bacterium or virus  

*'''Endogenous vaccines''' are where the [[Adaptive Immune System - WikiBlood#Antigen Recognition|antigen]] are made as new proteins by the cell, bacterium or virus  

**Involves MHC class I processing

**Involves [[MHC - WikiBlood#MHC I|MHC class I]] processing

**E.g. live virus, recombinant virus and DNA vaccines

**E.g. live virus, recombinant virus and DNA vaccines

*'''Exogenous vaccines''' are when the antigen is processed from the outside by endocytosis without any new proteins being made by the host cell  

*'''Exogenous vaccines''' are when the [[Adaptive Immune System - WikiBlood#Antigen Recognition|antigen]] is processed from the outside by endocytosis without any new proteins being made by the host cell  

**involves MHC class II processing

**involves [[MHC - WikiBlood#MHC II|MHC class II]] processing

**E.g. Inactivated and subunit vaccines

**E.g. Inactivated and subunit vaccines