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Skin Immunologic - Pathology (view source)
Revision as of 11:07, 11 October 2008
, 11:07, 11 October 2008→Autoimmune reactions
==Autoimmune reactions==
==Autoimmune reactions==
===Bullous pemphigoid===
===Bullous pemphigoid===
===Pemphigus===
===Pemphigus===
*Blistering diseases
*Autoantibodies bind to desmosomal proteins -> cell adhesion disrupted -> vesicles
*Types:
**'''Pemphigus vulgaris'''
***Rare, severe form
***Cats and dogs
***Vesicles or bullae -> erosions and ulcers
***Involves oral cavity, mucocutaneous junctions and skin
***Microscopically:
****Suprabasilar vesiculation and row of basal cells adhering to basement membrane
****Superficial perivascular dermatitis