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*Has been a major pathogen of dogs prior to vaccination
 
*Has been a major pathogen of dogs prior to vaccination
 
====Pathogenesis====
 
====Pathogenesis====
*Variable mortality depending on virulence
  −
*May occur subclinically
  −
*Involvement of central nervous system generally results in death
   
*Aerosol infection
 
*Aerosol infection
 
*Infects alveolar [[Macrophages - WikiBlood|macrophages]] or [[Oropharynx - Pathology|oropharynx]]
 
*Infects alveolar [[Macrophages - WikiBlood|macrophages]] or [[Oropharynx - Pathology|oropharynx]]
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**Secondary pyogenic infections associated with immunosuppression and damage to epithelia
 
**Secondary pyogenic infections associated with immunosuppression and damage to epithelia
 
**Recovered animals may have persistent or spasmodic chorea
 
**Recovered animals may have persistent or spasmodic chorea
**The severity of the disease may vary; if enough neutralising antibody develops in the early stages, the virus maybe kept restricted largely to the lymph nodes.
+
**The severity of the disease may vary; if enough neutralising antibody develops in the early stages, the virus maybe kept restricted largely to the lymph nodes
 +
*Variable mortality depending on virulence
 +
*May occur '''subclinically'''
 +
*Involvement of central nervous system generally results in death
 +
 
 
====Diagnosis====
 
====Diagnosis====
 
*May present as series of infections
 
*May present as series of infections
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