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→Pathogenesis
*Has been a major pathogen of dogs prior to vaccination
*Has been a major pathogen of dogs prior to vaccination
====Pathogenesis====
====Pathogenesis====
*Aerosol infection
*Aerosol infection
*Infects alveolar [[Macrophages - WikiBlood|macrophages]] or [[Oropharynx - Pathology|oropharynx]]
*Infects alveolar [[Macrophages - WikiBlood|macrophages]] or [[Oropharynx - Pathology|oropharynx]]
**Secondary pyogenic infections associated with immunosuppression and damage to epithelia
**Secondary pyogenic infections associated with immunosuppression and damage to epithelia
**Recovered animals may have persistent or spasmodic chorea
**Recovered animals may have persistent or spasmodic chorea
**The severity of the disease may vary; if enough neutralising antibody develops in the early stages, the virus maybe kept restricted largely to the lymph nodes.
**The severity of the disease may vary; if enough neutralising antibody develops in the early stages, the virus maybe kept restricted largely to the lymph nodes
*Variable mortality depending on virulence
*May occur '''subclinically'''
*Involvement of central nervous system generally results in death
====Diagnosis====
====Diagnosis====
*May present as series of infections
*May present as series of infections