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→Bioavailability
====Bioavailability====
====Bioavailability====
This is the fraction of the administered drug that actually reaches the systemic circulation in its active form. It is expressed as a percentage of the total amount administered and is calculated using plasmas drug concentrations.
This is the fraction of the administered drug that actually reaches the systemic circulation in its active form. It is expressed as a percentage of the total amount administered and is calculated using plasma drug concentrations.
To calculate bioavailability a curve of time against plasma concentration of a drug must be drawn in both it's intravenous form and then whichever form is underinvestigation, say intramuscular. Then use the following equation to calcute it:
Bioavailability = (Area Under Curve IM/Area under curve IV) x 100%