Changes

Jump to navigation Jump to search
1 byte removed ,  14:18, 22 October 2008
Line 145: Line 145:       −
The '''Volume of Distribution (V<sub>d</sub>)''' is a measure of the volume of fluid needed tocontain the total amount of drug at its plasma concentration.  
+
The '''Volume of Distribution (V<sub>d</sub>)''' is a measure of the volume of fluid needed to contain the total amount of drug at its plasma concentration.  
    
V<sub>d</sub> depends upon the ability of a drug to enter plamsa and interstitial fluid and to cross cell membranes and gives a good indication of the extent of drug distribution.
 
V<sub>d</sub> depends upon the ability of a drug to enter plamsa and interstitial fluid and to cross cell membranes and gives a good indication of the extent of drug distribution.
Line 154: Line 154:  
* Very High (>1l/kg) - concentrated in a body fluid other than plasma and there may be bound residues eg i fat
 
* Very High (>1l/kg) - concentrated in a body fluid other than plasma and there may be bound residues eg i fat
   −
Lipid-soluble drugs reach all compartments and can accumulate in fat. Whilst lipi-insoluble drugs are mainly contained in plasma and interstitial fluids; they are usually incapable of crossing the blood-brain barrier.  
+
Lipid-soluble drugs reach all compartments and can accumulate in fat. Whilst lipi-insoluble drugs are mainly contained in plasma and interstitial fluids; they are usually incapable of crossing the blood-brain barrier.
 
      
==Metabolism==
 
==Metabolism==
3,320

edits

Navigation menu