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→Distribution
* Low (0.2l/kg) - drug confined to plasma and interstitial space
* Low (0.2l/kg) - drug confined to plasma and interstitial space
* Intermediate (0.6l/kg) - drug enters total body water
* Intermediate (0.6l/kg) - drug enters total body water
* Very High (>1l/kg) - concentrated in a body fluid other than plasma and there may be bound residues eg i fat
* Very High (>1l/kg) - concentrated in a body fluid other than plasma and there may be bound residues eg fat
Lipid-soluble drugs reach all compartments and can accumulate in fat. Whilst lipi-insoluble drugs are mainly contained in plasma and interstitial fluids; they are usually incapable of crossing the blood-brain barrier.
Lipid-soluble drugs reach all compartments and can accumulate in fat. Whilst lipi-insoluble drugs are mainly contained in plasma and interstitial fluids; they are usually incapable of crossing the blood-brain barrier.