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New page: {{unfinished}} {{toplink |linkpage =Viruses |linktext =VIRUSES |sublink1=Picornaviridae |subtext1=PICORNAVIRUSES |pagetype =Bugs }} <br> ====Morphology==== *Very small (25nm) RNA virus *...
{{unfinished}}
{{toplink
|linkpage =Viruses
|linktext =VIRUSES
|sublink1=Picornaviridae
|subtext1=PICORNAVIRUSES
|pagetype =Bugs
}}
<br>
====Morphology====
*Very small (25nm) RNA virus
*12 capsomeres (1 per vertex)
*5 subunits per capsomere
*1 molecule of virus protein (VP) per subunit
*4 virus proteins (VP1-VP4)
*VP1 is the attachment protein
====Antigenicity====
*FMDV was the first animal virus in which serotypes were isolated
*To date, there are (important in bold):
**'''Oise (O)'''
**'''Allemagne (A)'''
**'''C (also German)'''
**South African Territories (SAT) 1, 2, and 3
**India (Asia-1)
*Each serotype has '''at lease three subtypes'''
*Serotype and subtype can be quickly identified by '''ELISA''' using guinea pig antisera
*'''All isolates are virulent'''
====Hosts====
*'''Cloven-hoofed animals, EXCLUDING the horse'''
**Cattle
**Sheep
**Goats
**Pigs
**Deer
**Elephants
**Wild ruminants: buffalo, kudu, impala, etc
====Pathogenesis====
*Primary replication in the upper respiratory tract, tonsils, or upper alimentary tract
*'''Aerosol''' excretion during this incubation period
*Viremia
*Virus targets stratum spinosum of stratified squamous epithelia and mucus mebranes
*Secondary vesicles appear after incubation of 2-14 days
*Appearance of lesions by age:
**0-2 days: unruptured vesicles
**1-3 days: newly ruptured vesicles with adherent epithelia at margins
**3-7 days: ruptured vesicles, loss of epithelia, no marked fibrous margin
**7-10+ days: open lesions with marked fibrous margin
*Prevalence of lesions by species:
**'''Pigs''':
***Lesion at '''coronary band''' means infection is usually less than a week old
***Lesions grow down claw at a rate of 1mm per week
**'''Cattle'''
***
====Epidemiology====
====Diagnosis====
====Control====
{{toplink
|linkpage =Viruses
|linktext =VIRUSES
|sublink1=Picornaviridae
|subtext1=PICORNAVIRUSES
|pagetype =Bugs
}}
<br>
====Morphology====
*Very small (25nm) RNA virus
*12 capsomeres (1 per vertex)
*5 subunits per capsomere
*1 molecule of virus protein (VP) per subunit
*4 virus proteins (VP1-VP4)
*VP1 is the attachment protein
====Antigenicity====
*FMDV was the first animal virus in which serotypes were isolated
*To date, there are (important in bold):
**'''Oise (O)'''
**'''Allemagne (A)'''
**'''C (also German)'''
**South African Territories (SAT) 1, 2, and 3
**India (Asia-1)
*Each serotype has '''at lease three subtypes'''
*Serotype and subtype can be quickly identified by '''ELISA''' using guinea pig antisera
*'''All isolates are virulent'''
====Hosts====
*'''Cloven-hoofed animals, EXCLUDING the horse'''
**Cattle
**Sheep
**Goats
**Pigs
**Deer
**Elephants
**Wild ruminants: buffalo, kudu, impala, etc
====Pathogenesis====
*Primary replication in the upper respiratory tract, tonsils, or upper alimentary tract
*'''Aerosol''' excretion during this incubation period
*Viremia
*Virus targets stratum spinosum of stratified squamous epithelia and mucus mebranes
*Secondary vesicles appear after incubation of 2-14 days
*Appearance of lesions by age:
**0-2 days: unruptured vesicles
**1-3 days: newly ruptured vesicles with adherent epithelia at margins
**3-7 days: ruptured vesicles, loss of epithelia, no marked fibrous margin
**7-10+ days: open lesions with marked fibrous margin
*Prevalence of lesions by species:
**'''Pigs''':
***Lesion at '''coronary band''' means infection is usually less than a week old
***Lesions grow down claw at a rate of 1mm per week
**'''Cattle'''
***
====Epidemiology====
====Diagnosis====
====Control====