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−*Porcine circovirus in Postweaning multisystemic wasting syndrome (PMWS) in [[Respiratory Viral Infections - Pathology#Postweaning multisystemic wasting syndrome (PMWS)|respiratory disease]]
+====Antigenicity====
+*Two serotypes:
+**PCV1 is harmless
+**PCV2 is virulent, causing:
+***Post-weaning Multisystemic Wasting Syndrome (PMWS) in young pigs
+***Porcine Dermatitis and Nephropathy Syndrome (PDNS) in older pigs
+====Pathogenesis====
+'''PMWS''':
+*Enlarged lymph nodes with lymphopenia as virus concentrates in germinal centers
+*Typically strikes '''weaners''' (8-12 weeks old)
+*Clinical signs:
+**Pale skin color
+**Jaundice
+**Enlarged lymph nodes and kidneys
+**Unthrifty appearance
+**Lameness
+**[[Respiratory Viral Infections - Pathology#Postweaning multisystemic wasting syndrome (PMWS)|Respiratory disease]]
+**Occasional diarrhoea
+*Large range of differentials, particularly [[Classical Swine Fever|Swine Fever]], African Swine Fever, ''Pasteurella'', and colisepticemia
+*Mortalities can reach 40% in an outbreak; nationally range from 4-10% annually
+'''PDNS''':
+*Can follow PMWS
+*Seen in '''growers and finishers'''
+*Presents as an immune-mediated '''necrotising vasculitis'''
+*Extensive hemorrhages of kidneys and skin, especially in the scrotal region, accompanied by pyrexia
+====Epidemiology====
+*Poor immune response
+*Transfer is '''orofecal''' and '''venereal'''
+====Diagnosis====
+*Clinical signs
+*Confirmed by PCR for PCV2 nucleic acid
+*However, positives can show NO clinical signs
+====Control====
+*No vaccines are available
+*Antibiotics to prevent secondary infection
+*Good ventilation, bio-security, and proper management
+*Passive antibody can be used in dire circumstances:
+**Viral serum from an adult pig and be injected peritoneally into piglets to stimulate a high anitbody response
+**Must be done by a vet and only within a single herd