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→Pharmacokinetic Considerations
* They are highly lipophilic and have a low degree of ionisation.
* They are highly lipophilic and have a low degree of ionisation.
* They are well absorbed from the gastrointestinal tract.
* They are well absorbed from the gastrointestinal tract.
* It isn't very well protein bound and so
* They aren't very well protein bound and so distribute well into extracellular and all intracellular fluids, including the CSF and prostatic fluid. They on do have a tendency to accumulate in the prostate, kidney and lung.
* As mentioned earlier they are capable of crossing cell membranes and will reach high concentrations intracellularly.
* They are excreted in both the bile and urine, 70% in the bile. Urine concentrations do reach high levels and remain high up to a day after a single dose.
* Some metabolites are active (such as ciprofloxacin of enrofloxacin). The formation of these active metabolites are highly species dependent as it depends upon the liver enzymes present in each species. For example the horse doesn't metabolise enrofloxacin very well.
==Side Effects and Contraindications==
==Side Effects and Contraindications==