Changes

* Works well against Mycoplasmas and Rickettsia.

* Works well against Mycoplasmas and Rickettsia.

* Poor activity against obligate anaerobes.

* Poor activity against obligate anaerobes.

* Their activity is very pH dependent wit their activity increasing above pH 7.4 and decreasing below pH 7.0.

* Their activity is very pH dependent with their activity increasing above pH 7.4 and decreasing below pH 7.0.

It should be noted that they are active at very low concentrations, they don't kill protective enterococci and anaerobes, and they will inhibit aminoglycoside and beta-lactam resistant bacteria.

It should be noted that they are active at very low concentrations, they don't kill protective enterococci and anaerobes, and they will inhibit aminoglycoside and beta-lactam resistant bacteria.

==Pharmacokinetic Considerations==

==Pharmacokinetic Considerations==

They are on the whole safe drugs with few side effects; those of significance are mentioned below:

They are on the whole safe drugs with few side effects; those of significance are mentioned below:

* High doses of enrofloxacin in cats can cause '''retinal blindness'''.

* High doses of enrofloxacin in cats can cause '''retinal blindness'''.

* In young growing dogs there can be '''erosion of the articular cartilages'''. This may be the case in other young growing animals, we however do know that this it is safe to use danofloxacin with calves.

* In young growing dogs there can be '''erosion of the articular cartilages'''. This may be the case in other young growing animals, we however do know that it is safe to use danofloxacin with calves.

* In man small CNS problems have been reported, as yet these haven't been confirmed in animals. They include nausea, vomiting, headaches and a predisposition of seizures if a patient is an epileptic. They is an increased risk of these problems if NSAIDs are given concurrently.

* In man small CNS problems have been reported, as yet these haven't been confirmed in animals. They include nausea, vomiting, headaches and a predisposition of seizures if a patient is an epileptic. There is an increased risk of these problems if NSAIDs are given concurrently.