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==Side Effects and Contraindications==
 
==Side Effects and Contraindications==
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Major reactions to sulphonamides are uncommon but the following are the most common of the side effects recorded:
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* Rapid intravenous injection can lead to muscle weakness, ataxia and collapse. This has only been recorded in cattle and horses.
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* They can precipitate in tubular fluid resulting in renal tubular damage.
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* Dobermans have had serious allergic reactions to them including immune-mediated polyarthritis, thrombocytopenia and haemolytic anaemia.
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* Severe hepatotoxicity has been noted in some dogs.
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* Long dosage regimens of Sulphonamides have resulted in keratoconjunctivitis sica/'dry eye' in dogs.
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* Sulphonamides inhibit thyroid gland function and so mild signs of hypothyroidism have been seen in dogs that have had intesive dosage regimens.
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