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→Spectrum of Activity
* They are inactive against anaerobes, this is because their action is dependent on oxygen-dependent active transport systems.
* They are inactive against anaerobes, this is because their action is dependent on oxygen-dependent active transport systems.
* They tend not to work well in purulent material.
* They tend not to work well in purulent material.
* If the local tissue environment is acidic the efficacy of the drug will be reduced.
===Pharmacokinetic Considerations===
===Pharmacokinetic Considerations===