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86 bytes added ,  10:13, 27 October 2008
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* They are inactive against anaerobes, this is because their action is dependent on oxygen-dependent active transport systems.
 
* They are inactive against anaerobes, this is because their action is dependent on oxygen-dependent active transport systems.
 
* They tend not to work well in purulent material.
 
* They tend not to work well in purulent material.
 +
* If the local tissue environment is acidic the efficacy of the drug will be reduced.
    
===Pharmacokinetic Considerations===
 
===Pharmacokinetic Considerations===
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