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→Triazoles
* It is used mainly to treat systemic fungal infections.
* It is used mainly to treat systemic fungal infections.
* Can cause anorexia and hepatic toxicity in dogs. If this occurs, stop therapy until appetite returns and then continue treatment at half the dose.
* Can cause anorexia and hepatic toxicity in dogs. If this occurs, stop therapy until appetite returns and then continue treatment at half the dose.
'''Fluconazole'''
* Can enter the CNS, unlike other azoles and so is used to treat feline cryptococcosis infections.
* It can give some mild levels of hepatotoxicity.
==Griseofluvin==
* This drug is a natural antifungal produced by ''Penicillium griseofulvum'', it works by interacting with fungal microtubules and halts mitosis and so is '''fungistatic'''.
* It has a narrow spectrum of activity only really inhibiting the growth of dermatophytes.
* It's oral bioavailability is variable depending on its formulation. It is deposited in new keratin in the hair, nails and skin, and moves from deep layers to superficial layers where it can then attack the ringworm.
* It is eliminated by hepatic metabolism.
* It is '''teratogenic''', so should never be given to pregnant animals. It can exacerbate liver damage and so function should be monitored. There have been reports in cats of bone marrow toxicity.
==Flucytosine==
* This drug is converted by fungal cells into 5-Fluorouracil, which inhibits DNA synthesis and so is fungistatic.
* It is very narrow spectrum and only works against ''Candida'' species and ''Cryptococcus neoformans'' infections.
* It has very good oral bioavailability and distrubutes widely throughout all tissue including the CSF.