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Skin Immunologic - Pathology (view source)
Revision as of 10:44, 29 October 2008
, 10:44, 29 October 2008→Lupus erythematosus
===Lupus erythematosus===
===Lupus erythematosus===
*'''Systemic (SLE)'''
**Multiple organs involved
**Cats, dogs, horses
**Immune dysregulation:
***Damaged T-cell suppressor function, either primary deficiency or antibody mediated
***Cytokine dysregulation
***Resulting B-cell hyperactivity -> antibodies to self antigens -> antigen-antibody complexes deposited in various tissues -> Type III hypersensitivity
**Lesions localised or generalised
**Erythema, alopecia, depigmentation, crusting and scaling, ulceration
**Microscopically: lymphohistiocytic interface dermatitis, thickened basement membrane, vasculitis, subepidermal vesicles, basal cell degeneration
*'''Discoid'''
**Milder variant of systemic
**Depigmentation, erythema, scaling, erosions, ulceration, crusting
**Usually involves nasal planum, dorsum of muzzle, occasionally pinnae, lips, oral mucosa or periocular area
**Microscopically: lichenoid interface dermatitis, often with lymphocytes, plasma cells, basal cell degeneration, loss of pigment
===Pemphigus===
===Pemphigus===