Changes

===Specific changes associated with disease===

===Specific changes associated with disease===

*[[Thyroid Gland - Pathology#Hypothyroidism|'''Hypothyroidism''']]:

*[[Thyroid Gland - Pathology#Hypothyroidism|'''Hypothyroidism''']]

**Grossly: endocrine alopecia mainly over trunk and neck

**Grossly: endocrine alopecia mainly over trunk and neck

**Microscopically: endocrine alopecia plus mucin within the dermis -> myxoedema (dermal thickening), acanthotic epidermal and follicular infundibular epithelium

**Microscopically: endocrine alopecia plus mucin within the dermis -> myxoedema (dermal thickening), acanthotic epidermal and follicular infundibular epithelium

**Secondary pyoderma is common

**Secondary pyoderma is common

*[[Adrenal Glands - Pathology#Adrenal_Hyperfunction|'''Hyperadrenocorticism''']]:

*[[Adrenal Glands - Pathology#Adrenal_Hyperfunction|'''Hyperadrenocorticism''']]

**Grossly: endocrine alopecia except on head and extremities, thin skin, comedones, easy bruising and poor wound healing, sometimes involves [[Adrenal Glands - Pathology#Pathophysiology_2|calcinosis cutis]]  

**Grossly: endocrine alopecia except on head and extremities, thin skin, comedones, easy bruising and poor wound healing, sometimes involves [[Adrenal Glands - Pathology#Pathophysiology_2|calcinosis cutis]]  

***In cats, skin is very easily torn

***In cats, skin is very easily torn

**Microscopically: epidermal, dermal and follicular atrophy, comedones, calcinosis cutis often with granulomatous inflammation and epidermal hyperplasia

**Microscopically: epidermal, dermal and follicular atrophy, comedones, calcinosis cutis often with granulomatous inflammation and epidermal hyperplasia

 

*[[Pituitary Gland - Pathology#Pituitary_Hypofunction|'''GH deficiency (hyposomatotropism)''']] [[Image:Flame follicles.jpg|right|thumb|125px|<small><center>'''Flame Follicles'''. Courtesy of A. Jefferies</center></small>]]

*[[Pituitary Gland - Pathology#Pituitary_Hypofunction|'''GH deficiency (hyposomatotropism)''']]:[[Image:Flame follicles.jpg|right|thumb|125px|<small><center>'''Flame Follicles'''. Courtesy of A. Jefferies</center></small>]]

**Retained puppy hair coat, endocrine alopecia, decreased dermal elastin and catagen follicles ('''Flame follicles''').

**Retained puppy hair coat, endocrine alopecia, decreased dermal elastin and catagen follicles ('''Flame follicles''').

**Grossly: thick, folded skin on head, neck and extremities, possibly with hypertrichosis

**Grossly: thick, folded skin on head, neck and extremities, possibly with hypertrichosis

**Microscopically: epidermal hyperplasia, dermal fibrosis, mucinous degeneration of dermis

**Microscopically: epidermal hyperplasia, dermal fibrosis, mucinous degeneration of dermis