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*Oropharyngeal infection followed by '''viremia'''
*Oropharyngeal infection followed by '''viremia'''
*2 distinct syndromes:
*2 distinct syndromes:
−
*#'''Myocarditis''' in puppies aged 3-8 weeks
+
#'''Myocarditis''' in puppies aged 3-8 weeks
−
***Virus targets rapidly dividing myocardium
+
#*Virus targets rapidly dividing myocardium
−
***Sudden death, '''fading puppy''' syndrome
+
#*Sudden death, '''fading puppy''' syndrome
−
***Now rare due to widespread passive immunity
+
#*Now rare due to widespread passive immunity
−
*#'''Enteritis''' in puppies >8 weeks of age
+
#'''Enteritis''' in puppies >8 weeks of age
−
***Virus targets intestinal crypts
+
#*Virus targets intestinal crypts
−
***Villi shorten, then destruction of cypt cells
+
#*Villi shorten, then destruction of cypt cells
−
***Gray, persistent, foul-smelling diarrhoea or hemorrhagic enteritis
+
#*Gray, persistent, foul-smelling diarrhoea or hemorrhagic enteritis
−
***High morbidity, low mortality (10%)
+
#*High morbidity, low mortality (10%)
====Epidemiology====
====Epidemiology====