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|pagetype = Drugs
 
|pagetype = Drugs
 
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Gastroprotective drugs are often used for the following reasons:
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* Gastric and duodenal ulceration
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* Gastritis
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* Reflux Oesphagitis
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* Rumenal Acidosis
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They following are the different classes of drugs that are used as gastroprotectives.
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==Antacids==
 
==Antacids==
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==Binding Agents==
 
==Binding Agents==
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An is example is '''sucralfate''' that is administered orally.
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It works by forming a viscous paste in an acidic environment, the binds and protects the mucosal surface. It also stimulates mucus and bicarbonate secretion and the production of prostaglandins.
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==Prostaglandin E Analogues==
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An example is '''misoprostol''' that is administered orally.
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It works by mimicing the endogenously produced prostaglandins that are gastroprotective. This will therefore inhibit H<sup>+</sup> production and increase mucus and bicarbonate production. It will also maintain normal mucosal blood flow.
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It should be used when Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are being used, as NSAIDs block prostoglandin formation and so the gastric lining will be more prone to damage.
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