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| *Serology required for identification | | *Serology required for identification |
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| + | ===''Leptospira'' |
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| + | *Motile, helical bacteria found in aquatic environments |
| + | *Require liquid media for culture |
| + | *Cause leptospirosis in all animals, which can range from mild urogenital tract infections to systemic diseases |
| + | *Organisms persist in kidney tubules or genital tract of carrier animals and are shed in urine |
| + | *Transmission via direct contact |
| + | *Serovars are fairly host-specific, causing mild disease in the maintenance host, with shedding in the urine |
| + | *Maintenance hosts may transmit the infection to incidental hosts, which are less susceptible to infection, but develop serious disease |
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| + | *Pathogenesis and pathogenicity |
| + | **Depends on virulence of the serovar and susceptibility of the host |
| + | **Leptospires invade tissues through moist skin or via mucous membranes, aided by their motility |
| + | **Leptospires may invade via receptor-mediatied endocytosis |
| + | **They disseminate through the body via the blood stream |
| + | **Antibodies clear organisms from the blood stream after about 10 days of infection |
| + | **Organisms may persist in the renal tubules, uterus, eye or meninges |
| + | **Evade phagocytosis possibly via macrophage apoptosis |
| + | **Damage red blood cell membranes and endothelial and liver cells, leading to haemolytic anaemia, jaundice, haemoglobinuria and haemorrhage in acute leptospirosis |
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| + | *Diagnosis |
| + | **Clinical signs and history of exposure |
| + | **Dark-field microscopy of urine may detect organisms |
| + | **Isolation from blood or urine by culture or animal inoculation |
| + | **Identificaiton or certain serovars using DNA probes and serology |
| + | **FLuorescent antibody technique for identification in tissues |
| + | **Silver impregnation |
| + | **Molecular techniques such as PCR |
| + | **Serology using microscopic agglutination test or ELISA |
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| + | *Clinical infections |
| + | **Cattle and sheep |
| + | ***Cattle are maintenance hosts for ''L. borgpetersenii'' serovar ''hardjo'' |
| + | ***''L. interrogans'' serovar ''hardjo'' is host-adapted to cattle |
| + | ***Acute disease in susceptible heifers, with fever and agalactia of all quarters; abortion and stillbirth may occur |
| + | ***Diagnosed by rising antibody titre in paired serum samples |
| + | ***Infection in sheep may cause abortion and agalactia |
| + | ***Urinary excretion can be reduced by administering dihydrostreptomycin or amoxycillin |
| + | ***Incactivated vaccines are of questionable efficacy |
| + | ***Serovars ''pomona, grippotyphosa'' and ''icterohaemorrhagiae'' cause pyrexia, haemoglobinurea, jaundice, anorexia, uraemia due to renal damage and death in calves and lambs |
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| + | **Horses |
| + | ***Clinical disease rare |
| + | ***May be maintenance host of serovar ''bratislava'', which causes abortion and stillbirth |
| + | ***Incidental hosts for serovar ''pomona'', suffering from abortion and renal disease |
| + | ***Chronic leptospirosis may cause an immune-mediated anterior uveitis |
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| + | **Pigs |
| + | ***The rodent-adapted serovars ''icterohaemorrhagica'' and ''copenhagenii'' cause acute disease in pigs |
| + | ***Severe disease in young pigs |
| + | ***Serovar ''pomona'' is the host-adapted species, and may be shed in the urine |
| + | ***Infections may cause abortions and stillbirths |
| + | ***Pigs are maintenance hosts for serovars ''tarassovi'' and ''bratislava'', which may cause reproductive failure |
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| + | **Dogs and cats |
| + | ***Serovars ''canicola'' and ''icterohaemorrhagica'' cause leptospirosis in dogs, but are vaccinated against |
| + | ***Serovars ''pomona'' and ''grippotyphosa'' are becoming important |
| + | ***The host-adapted serovar ''canicolar'' causes renal failure in puppies |
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| [[Brachyspira hyodysenteriae]] | | [[Brachyspira hyodysenteriae]] |
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| [[Leptospira]] | | [[Leptospira]] |