Changes

*Ticks feed continuously

*Ticks feed continuously

*Tick saliva flows into host

*Tick saliva flows into host and contains

**Histamine blocking agents to minismise the host inflammatory response

**Histamine blocking agents to minimise the host inflammatory response

**Anticoagulents to ensure the free flow of blood

**Anticoagulants to ensure the free flow of blood

**Cytolysins to enlarge the feeding lesion

**Cytolysins to enlarge the feeding lesion

**Vasoactive mediators, enterases and carbohydrate splitting enzymes to increase the vascular permeability, facilitating feeding

**Vasoactive mediators, enterases and carbohydrate splitting enzymes to increase the vascular permeability, facilitating feeding