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Some NSAIDs, such as aspirin and ketoprofen, can also have '''negative effects on coagulation'''. Platelet aggregation is caused by prostaglandins and thromboxanes which are produced by platelets using a COX-1 pathway. Inhibition of this pathway can therefore cause bleeding.
Some NSAIDs, such as aspirin and ketoprofen, can also have '''negative effects on coagulation'''. Platelet aggregation is caused by prostaglandins and thromboxanes which are produced by platelets using a COX-1 pathway. Inhibition of this pathway can therefore cause bleeding.
Because of these issues, the use of COX-2 selective drugs is desirable. These inclue [[NSAIDs#Carprfden|carprofen]], [[NSAIDs#Meloxicam|meloxicam]] and nimesulide.
Because of these issues, the use of COX-2 selective drugs is desirable. These include [[NSAIDs#Carprfden|carprofen]], [[NSAIDs#Meloxicam|meloxicam]] and nimesulide.
===Drug Interactions===
===Drug Interactions===