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New page: {{unfinished}} '''Sevoflurane''' is very similar to isoflurane but is less potent. However, it's odour is less pungent making it more suitable for mask induction, but can a...
{{unfinished}}
'''Sevoflurane''' is very similar to [[Isoflurane|isoflurane]] but is less potent. However, it's odour is less pungent making it more suitable for mask induction, but can also be used as a maintentance agent. It is becoming more popular in veterinary anaesthesia.
==Pharmacokinetics==
Sevoflurane is also a halogenated ether. It is also stable and nonflammable. Alkaline carbon dioxide absorbents react with sevoflurane to produced a potentially toxic compound. This can be influenced by environmental temperature, sevoflurane concentrations, use of baralyme rather then sodalime, low flow rates and already exposed absorbents. The '''blood:gas partition coefficient''' is very low, meaning that has a rapid onset of action. It has a high tissue solubility however, which means that recovery is more prolonged compared to [[Isoflurane|isoflurane]] or [[Halothane|halothane]]. The '''MAC''' of sevoflurane is approximately ''2.3%'' and is therefore less potent the other agents. Sevoflurane undergoes a small amount of hepatic metabolism.
==Adverse Effects==
===Central Nervous System===
*Increases intracranial pressure due to cerebral vasodilation.
===Cardiovascular System===
*Mild myocardial contractility depression.
*Decreased arterial blood pressure and systemic vascular resistance.
===Other Systems===
*There is an increase in hepatic artery flow, but reduced in the hepatic portal vein, like isoflurane.
==Contraindications==
*It is advisable to avoid the use of sevoflurane in patients with renal disease as there is a potential for further renal damage.
'''Sevoflurane''' is very similar to [[Isoflurane|isoflurane]] but is less potent. However, it's odour is less pungent making it more suitable for mask induction, but can also be used as a maintentance agent. It is becoming more popular in veterinary anaesthesia.
==Pharmacokinetics==
Sevoflurane is also a halogenated ether. It is also stable and nonflammable. Alkaline carbon dioxide absorbents react with sevoflurane to produced a potentially toxic compound. This can be influenced by environmental temperature, sevoflurane concentrations, use of baralyme rather then sodalime, low flow rates and already exposed absorbents. The '''blood:gas partition coefficient''' is very low, meaning that has a rapid onset of action. It has a high tissue solubility however, which means that recovery is more prolonged compared to [[Isoflurane|isoflurane]] or [[Halothane|halothane]]. The '''MAC''' of sevoflurane is approximately ''2.3%'' and is therefore less potent the other agents. Sevoflurane undergoes a small amount of hepatic metabolism.
==Adverse Effects==
===Central Nervous System===
*Increases intracranial pressure due to cerebral vasodilation.
===Cardiovascular System===
*Mild myocardial contractility depression.
*Decreased arterial blood pressure and systemic vascular resistance.
===Other Systems===
*There is an increase in hepatic artery flow, but reduced in the hepatic portal vein, like isoflurane.
==Contraindications==
*It is advisable to avoid the use of sevoflurane in patients with renal disease as there is a potential for further renal damage.