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* A non-infectious [[CNS Inflammation - Pathology|central nervous inflammatory disease]]
 
* A non-infectious [[CNS Inflammation - Pathology|central nervous inflammatory disease]]
 
* Polyneuritis equi (PNE) is an uncommon disease which affects mature horses
 
* Polyneuritis equi (PNE) is an uncommon disease which affects mature horses
* Formerly known as 'cauda equina syndrome' or 'cauda equine neuritis'
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* Formerly known as 'cauda equina syndrome' or 'cauda equina neuritis'
 
* May occur as:
 
* May occur as:
 
** A disease effecting the spinal nerve roots and ganglia of the cauda equina.
 
** A disease effecting the spinal nerve roots and ganglia of the cauda equina.
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** Protein is usually elveated.
 
** Protein is usually elveated.
 
* Histologically, the disease presents as a severe, chronic, destructive lymphocytic and histiocytic polyradiculoneuritis.
 
* Histologically, the disease presents as a severe, chronic, destructive lymphocytic and histiocytic polyradiculoneuritis.
* Considered to be caused by a T-lymphocyte mediated response to myelin, followed by destruction of myelin and axons by macrophages
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* Pathogenesis not completely understood, but considered to be caused by a T-lymphocyte mediated response to myelin, followed by destruction of myelin and axons by macrophages
 
* Disease appears similar to:
 
* Disease appears similar to:
 
** Guillain-Barré Syndrome (GBS), an autoimmune demyelinating diease in humans
 
** Guillain-Barré Syndrome (GBS), an autoimmune demyelinating diease in humans
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** Sacral/coccygeal trauma
 
** Sacral/coccygeal trauma
 
** Equine motor neuron disease
 
** Equine motor neuron disease
** Abberant parasite migration (e.g. ''Strongylus'')
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** Abberant parasite migration (e.g. ''Strongylus spp.'')
 
** In endemic areas, ''Sarcocystis neurona'' myelitis (equine protozoal myelitis), rabies and ''rhodococcus equi'' myeloencepahlitis should also be considered.
 
** In endemic areas, ''Sarcocystis neurona'' myelitis (equine protozoal myelitis), rabies and ''rhodococcus equi'' myeloencepahlitis should also be considered.

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