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<p>The spleen lies vertically on the left side of the cranial abdomen. It is attached to the greater curvature of the [[Alimentary - Anatomy & Physiology#Stomach|stomach]] by the gastrosplenic ligament. The spleen is enclosed in a capsule of fibrous and elastic tissue that extends into the parenchyma as trabeculae.  </p>

<p>The spleen lies vertically on the left side of the cranial abdomen. It is attached to the greater curvature of the [[Alimentary - Anatomy & Physiology#Stomach|stomach]] by the gastrosplenic ligament. The spleen is enclosed in a capsule of fibrous and elastic tissue that extends into the parenchyma as trabeculae.  </p>

<p> The parenchyma is supported by a fine mesh of reticular fibres and is divided into two types of tissue, the red and the white pulp. The red and white pulp are separated by the marginal sinus.</p>

<p> The parenchyma is supported by a fine mesh of reticular fibres and is divided into two types of tissue, the red and the white pulp, which are separated by the marginal sinus.</p>

===Red Pulp===

===Red Pulp===

<p>The red pulp makes up the majority of the spleen and is composed of a network of cell cords in series with vascular sinuses. The splenic cords contain [[Macrophages - WikiBlood|macrophages]], [[B cell differentiation - WikiBlood#Plasma cells|plasma cells]], [[Lymphocytes - WikiBlood|lymphocytes]] and other mature blood cells e.g. [[Granulocyte - WikiBlood|granulocytes]] and [[Erythrocytes - WikiBlood|erythrocytes]].  While the vascular sinuses are wide vascular channels lined with endothelial cells. Blood cells and fluid can pass into the splenic cords through fenestrations in the sinus walls. </p>

<p>The red pulp makes up the majority of the spleen and is composed of a network of cell cords in series with vascular sinuses. The splenic cords contain [[Macrophages - WikiBlood|macrophages]], [[B cell differentiation - WikiBlood#Plasma cells|plasma cells]], [[Lymphocytes - WikiBlood|lymphocytes]] and other mature blood cells e.g. [[Granulocyte - WikiBlood|granulocytes]] and [[Erythrocytes - WikiBlood|erythrocytes]].  While the vascular sinuses are wide vascular channels lined with endothelial cells. Blood cells and fluid can pass into the splenic cords through fenestrations in the sinus walls. </p>