Changes

*Connect with the venous sinuses, or  

*Connect with the venous sinuses, or  

*Terminate with open ends in the splenic cords

*Terminate with open ends in the splenic cords

Blood released into the splenic cords, either from the sinuses or capillaries eventually filters back into the sinus network. The sinuses converge and empty into trabecular veins, which then merge into a single splenic vein which then empties into the portal vein.</p>

Blood released into the splenic cords, either from the sinuses or capillaries, eventually filters back into the sinus network. The sinuses converge and empty into trabecular veins, which then merge into a single splenic vein which then empties into the portal vein.</p>

<p>[[Lymphocytes - WikiBlood|Lymphocytes]] in the arterial blood migrate from the red pulp sinuses, through the splenic cords and through the white pulp. [[Lymphocytes - WikiBlood#T cells|T cells]] specifically migrate through the PALS and [[Lymphocytes - WikiBlood#B cells|B cells]] specifically migrate through the follicles. Antigen in the blood is filtered by the large numbers of [[Macrophages - WikiBlood|macrophages]] in the splenic cords and white pulp.</p>

<p>[[Lymphocytes - WikiBlood|Lymphocytes]] in the arterial blood migrate from the red pulp sinuses, through the splenic cords and through the white pulp. [[Lymphocytes - WikiBlood#T cells|T cells]] specifically migrate through the PALS and [[Lymphocytes - WikiBlood#B cells|B cells]] specifically migrate through the follicles. Antigen in the blood is filtered by the large numbers of [[Macrophages - WikiBlood|macrophages]] in the splenic cords and white pulp.</p>

====Species Differences====

====Species Differences====

*Branches regularly as it passes through the spleen in horses and pigs

*Branches regularly as it passes through the spleen in horses and pigs

*Branches before it reaches the spleen in dogs and cats</p>

*Branches before it reaches the spleen in dogs and cats</p>

===Innervation===

===Innervation===

Innervation is purely sympathetic<ref>{{citation|initiallast = Nance|initialfirst = D.M|finallast = Sanders|finalfirst = V.M|year = 2007|jtitle = Autonomic innervation and regulation of the immune system (1987-2007)|jor = Brain, Behavior, and Immunity|vol = 21(6)|range = 736-745}}</ref> and nerve fibres travel with the artery into the spleen.

Innervation is purely sympathetic<ref>{{citation|initiallast = Nance|initialfirst = D.M|finallast = Sanders|finalfirst = V.M|year = 2007|jtitle = Autonomic innervation and regulation of the immune system (1987-2007)|jor = Brain, Behavior, and Immunity|vol = 21(6)|range = 736-745}}</ref> and nerve fibres travel with the artery into the spleen.